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We recommend this protocol From Dr Jean Dodd:
Total of 3 doses ONLY
Age of Pups - Vaccine - Type
9 weeks MLV Distemper/Parvovirus only (e.g. Intervet Progard Puppy)
12 weeks MLV Distemper/Parvovirus only (e.g. Intervet Progard Puppy)
16-20 weeks MLV Distemper/Parvovirus only (e.g. Intervet Progard Puppy)
24 weeks or older, if allowable by law Killed Rabies Vaccine
1 year MLV Distemper/Parvovirus only booster
1 year ( give 3-4 weeks apart from Dist/Parvo booster) Killed 3 year rabies vaccine
MLV=modified-live virus
After 1 year, annually measure serum antibody titers against specific canine infectious agents such
 as distemper and parvovirus. This is especially recommended for animals previously experiencing 
adverse vaccine reactions or breeds at higher risk for such reactions
 (e.g., Weimaraner, Akita, American Eskimo, Great Dane).
Another alternative to booster vaccinations is homeopathic nosodes. 
This option is considered an unconventional treatment that has not been scientifically proven to be 
efficacious.  One controlled parvovirus nosode study did not adequately protect puppies under 
challenged conditions. However, data from Europe and clinical experience in North America 
support its use. If veterinarians choose to use homeopathic nosodes, their clients should be provided
with an appropriate disclaimer and written informed consent should be obtained.
I use only killed 3 year rabies vaccine for adults and give it separated from other vaccines by 3-4 weeks. 
In some states, they may be able to give titer test result in lieu of booster.
I do NOT use Bordetella, corona virus, leptospirosis or Lyme vaccines unless these diseases are endemic
in the local area or specific kennel. Furthermore, the currently licensed leptospira bacterins do not contain
the serovars causing the majority of clinical leptospirosis today.
I do NOT recommend vaccinating bitches during estrus, pregnancy or lactation.
W. Jean Dodds, DVM